Immanuel was founded in 1870 by immigrants from Germany. Finding no Lutheran church in Alexandria, they established one. After worshiping in rented space for a short time, they bought property at 811 Cameron in Old Town Alexandria. Immanuel started a parochial school in 1871. The school had to close during the Great War.
Originally independent, Immanuel joined the Lutheran Church—Missouri Synod in 1880.
When Immanuel moved to its current location on Russell Road in 1943, the leaders began construction of a new school, which opened in 1944. It has been in continuous operation since then. Notable figures during this period were Pastor Willner Mensing and Teacher Ralph Behrens, who served as the school's principal.
Rudolph A. Bischoff August 1870 - August 1873
E. J. Fleckenstein August 1873 - August 1877
J. A. Schwoy June 1884 - August 1893
L. Glaser August 1893 - 1895
J. M. Eberlein August 1896 - 1899
M. L. Luecke February 1900 - 1904
John J. May October 1904 - April 1909
H. W. Gross December 1909 - May 1910
P. O. Tweten May 1910 - July 1911
C. F. Brandt August 1912 - October 1917
Carl J. Goette September 1918 - April 1930
Elmer F. Leonhardt August 1930 - September 1940
Willner D. Mensing October 1940 - October 1976
Robert Koch October 1977 - July 1979
Clifford W. Gade July 1980 - September 1983
Thomas L. Palke July 1985 - 1999
Christopher S. Esget June 2001 - Present
Richard Gaub (assistant) 2004 - 2007
Charles McClean (assistant) March 2010 - May 2013
Robert Kieselowsky (assistant) July 2011 - June 2012
Peter J. Eckardt August 2005 - Present